Publications
Online Publication Lists:
2023
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Henriette O’Geen, Ulrika Beitnere, Miranda S. Garcia, Anna Adhikari, David L. Cameron, Timothy A. Fenton, Nycole A. Copping, Peter Deng, Samantha Lock, Julian A.N.M. Halmai, Isaac J. Villegas, Jiajian Liu, Danhui Wang, Kyle D. Fink, Jill L. Silverman, and David J. Segal. Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model. Molecular Therapy. 2023;31(4):1088-1105. doi:10.1016/j.ymthe.2023.01.013
2022
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Adhikari A, Buchanan FKB, Fenton TA, Cameron DL, Halmai JANM, Copping NA, Fink KD, Silverman JL. Touchscreen Cognitive Deficits, Hyperexcitability, and Hyperactivity in Males and Females Using Two Models of Cdkl5 Deficiency. Hum Mol Genet. 2022 Apr 21:ddac091. doi: 10.1093/hmg/ddac091. Epub ahead of print. PMID: 35445702.
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DeFelice BC, Fiehn O, Belafsky P, Ditterich C, Moore M, Abouyared M, Beliveau AM, Farwell DG, Bewley AF, Clayton SM, Archard JA, Pavlic J, Rao S, Kuhn M, Deng P, Halmai J, Fink KD, Birkeland AC, Anderson JD. Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids. DiagnosticsDiagnostics (Basel). 2022 Mar 24;12(4):797. doi: 10.3390/diagnostics12040797. PMID: 35453845; PMCID: PMC9024570.
2021
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Deng P, Halmai J, Waldo JJ, Fink KD. Cell-Based Delivery Approaches for DNA-Binding Domains to the Central Nervous System.. Curr Neuropharmacol. 2021;19(12):2125-2140. doi: 10.2174/1570159X19666210517144044. PMID: 33998992; PMCID: PMC9185769.
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Anna Adhikari, Nycole A Copping, Julie Beegle, David L Cameron, Peter Deng, Henriette O’Geen, David J Segal, Kyle D Fink, Jill L Silverman, Joseph S Anderson, Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells, Human Molecular Genetics, Volume 30, Issue 12, 15 June 2021, Pages 1067–1083, https://doi.org/10.1093/hmg/ddab104
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Heather Dahlenburg, David Cameron, Sheng Yang, Angelica Bachman, Kari Pollock, Whitney Cary, Missy Pham, Kyle Hendrix, Jeannine White, Haley Nelson, Peter Deng, Joseph S. Anderson, Kyle Fink, Jan Nolta, A Novel Huntington's Disease Mouse Model to Assess the Role of Neuroinflammation on Disease Progression and to Develop Human Cell Therapies, Stem Cells Translational Medicine, Volume 10, Issue 7, July 2021, Pages 1033–1043, https://doi.org/10.1002/sctm.20-0431
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Copping, N.A., McTighe, S.M., Fink, K.D. et al. Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome. Neurotherapeutics 18, 1535–1547 (2021). https://doi.org/10.1007/s13311-021-01082-x
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Belafsky P, Clayton SM, Archard JA, Pavlic JP, Rao S, Farwell D G, Kuhn M, Deng P, Halmai J, Bauer G, Fink KD, Fury B, Perotti NH, Walker JE, Beliveau AM, Birkeland A, Abouyared M, Cary W, Nolta JA, Anderson JD. Model of radiation-induced ambulatory dysfunction. J Med Sci 2021;41:201-10
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Deng P, Halmai JANM, Beitnere U, Cameron D, Martinez ML, Lee CC, Waldo JJ, Thongphanh K, Adhikari A, Copping N, Petkova SP, Lee RD, Lock S, Palomares M, O'Geen H, Carter J, Gonzalez CE, Buchanan FKB, Anderson JD, Fierro FA, Nolta JA, Tarantal AF, Silverman JL, Segal DJ, Fink KD. An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models. Front Mol Neurosci. 2022 Jan 27;14:789913. doi: 10.3389/fnmol.2021.789913. PMID: 35153670; PMCID: PMC8829036.
2020
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Carter JL, Halmai JANM, Fink KD. The iNs and Outs of Direct Reprogramming to Induced Neurons. Front Genome Ed. 2020 Sep 4;2:7. doi: 10.3389/fgeed.2020.00007. PMID: 34713216; PMCID: PMC8525349.
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Julian A N M Halmai, Peter Deng, Casiana E Gonzalez, Nicole B Coggins, David Cameron, Jasmine L Carter, Fiona K B Buchanan, Jennifer J Waldo, Samantha R Lock, Johnathon D Anderson, Henriette O’Geen, David J Segal, Jan Nolta, Kyle D Fink, Artificial escape from XCI by DNA methylation editing of the CDKL5 gene, Nucleic Acids Research, Volume 48, Issue 5, 18 March 2020, Pages 2372–2387, https://doi.org/10.1093/nar/gkz1214
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Berg, E.L., Pride, M.C., Petkova, S.P. et al. Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome. Transl Psychiatry 10, 39 (2020). https://doi.org/10.1038/s41398-020-0720-2
2019
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O’Geen, H., Bates, S.L., Carter, S.S. et al. Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. Epigenetics & Chromatin 12, 26 (2019). https://doi.org/10.1186/s13072-019-0275-8
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M.R. Showalter, B. Wancewicz, O. Fiehn, J.A. Archard, S. Clayton, J. Wagner, P. Deng, J. Halmai, K.D. Fink, G. Bauer, et al. Primed mesenchymal stem cells package exosomes with metabolites associated with immunomodulation Biochem. Biophys. Res. Commun., 512 (2019), pp. 729-735
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Oliver Yuan, Clayton Lin, Joseph Wagner, Joseph S. Anderson, Joehleen A. Archard, Peter Deng, Julian Halmai, Gerhard Bauer, Kyle D. Fink, Brian Fury, Nicholas H. Perotti, Jon E. Walker, Kari Pollock, Michelle Apperson, Janelle Butters, Peter Belafsky, D. Gregory Farwell, Maggie Kuhn, Jan Nolta, and Johnathon D. Anderson. Exosomes Derived from Human Primed Mesenchymal Stem Cells Induce Mitosis and Potentiate Growth Factor Secretion.Stem Cells and Development.Mar 2019.398-409.http://doi.org/10.1089/scd.2018.0200
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Glikmann-Johnston Y, Fink KD, Deng P, Torrest A, Stout JC. Spatial memory in Huntington's disease: A comparative review of human and animal data. Neurosci Biobehav Rev. 2019 Mar;98:194-207. doi: 10.1016/j.neubiorev.2019.01.015. Epub 2019 Jan 15. PMID: 30658070.
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Deng, P., Carter, S., Fink, K. (2019). Design, Construction, and Application of Transcription Activation-Like Effectors. In: Manfredsson, F., Benskey, M. (eds) Viral Vectors for Gene Therapy. Methods in Molecular Biology, vol 1937. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9065-8_3